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Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes
المؤلفون المشاركون
Kuonen, R.
Kunz, M.
Weissenstein, U.
Baumgartner, S.
Heusser, Peter
Urech, K.
Hostanska, K.
Estko, M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Viscum album L.
lipophilic extract (VALE) contains pharmacologically active pentacyclic triterpenes that are known to exhibit immunomodulatory, antitumor, and wound healing activity.
Preliminary clinical observations indicate that VALE was able to influence cutaneous wound healing in vivo.
The objective of this study was to investigate wound closure related properties of VALE in vitro.
As measured in a wound healing assay, VALE and its predominant triterpene oleanolic acid (OA) significantly and dose dependently promoted the migration of NIH/3T3 fibroblasts in vitro, thereby leading to an enhanced wound closure.
Compared to the negative control, maximal stimulation by 26.1% and 26.2%, respectively, was attained with 10 μg/mL VALE and 1 μg/mL OA.
Stimulation of proliferation in NIH/3T3 fibroblasts by VALE and OA could be excluded.
At higher concentrations both substances affected proliferation and viability of NIH/3T3 fibroblasts and HaCat keratinocytes.
In the toxic range of concentrations of VALE and OA, migration of NIH/3T3 fibroblasts was suppressed.
The extent of the stimulatory effect on cell migration of VALE quite closely corresponded to the effect expected by the concentrations of OA contained in the crude extract VALE.
These data support the casual observation that Viscum album L.
lipophilic extract might modulate wound healing related processes in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuonen, R.& Weissenstein, U.& Urech, K.& Kunz, M.& Hostanska, K.& Estko, M.…[et al.]. 2013. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuonen, R.…[et al.]. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuonen, R.& Weissenstein, U.& Urech, K.& Kunz, M.& Hostanska, K.& Estko, M.…[et al.]. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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