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Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes
Joint Authors
Kuonen, R.
Kunz, M.
Weissenstein, U.
Baumgartner, S.
Heusser, Peter
Urech, K.
Hostanska, K.
Estko, M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Viscum album L.
lipophilic extract (VALE) contains pharmacologically active pentacyclic triterpenes that are known to exhibit immunomodulatory, antitumor, and wound healing activity.
Preliminary clinical observations indicate that VALE was able to influence cutaneous wound healing in vivo.
The objective of this study was to investigate wound closure related properties of VALE in vitro.
As measured in a wound healing assay, VALE and its predominant triterpene oleanolic acid (OA) significantly and dose dependently promoted the migration of NIH/3T3 fibroblasts in vitro, thereby leading to an enhanced wound closure.
Compared to the negative control, maximal stimulation by 26.1% and 26.2%, respectively, was attained with 10 μg/mL VALE and 1 μg/mL OA.
Stimulation of proliferation in NIH/3T3 fibroblasts by VALE and OA could be excluded.
At higher concentrations both substances affected proliferation and viability of NIH/3T3 fibroblasts and HaCat keratinocytes.
In the toxic range of concentrations of VALE and OA, migration of NIH/3T3 fibroblasts was suppressed.
The extent of the stimulatory effect on cell migration of VALE quite closely corresponded to the effect expected by the concentrations of OA contained in the crude extract VALE.
These data support the casual observation that Viscum album L.
lipophilic extract might modulate wound healing related processes in vivo.
American Psychological Association (APA)
Kuonen, R.& Weissenstein, U.& Urech, K.& Kunz, M.& Hostanska, K.& Estko, M.…[et al.]. 2013. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493035
Modern Language Association (MLA)
Kuonen, R.…[et al.]. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-493035
American Medical Association (AMA)
Kuonen, R.& Weissenstein, U.& Urech, K.& Kunz, M.& Hostanska, K.& Estko, M.…[et al.]. Effects of Lipophilic Extract of Viscum album L. and Oleanolic Acid on Migratory Activity of NIH3T3 Fibroblasts and on HaCat Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-493035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493035