![](/images/graphics-bg.png)
The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms
المؤلفون المشاركون
Choi, Byung Tae
Cho, Su In
Bae, Sun Sik
Ha, Jung Min
Park, Sun Haeng
Kim, Young Whan
Kim, Ji Hyun
Shin, Hwa Kyoung
Lee, Guem San
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dangkwisoo-San (DS) is an herbal extract that is widely used in traditional Korean medicine to treat traumatic ecchymosis and pain by promoting blood circulation and relieving blood stasis.
However, the effect of DS in cerebrovascular disease has not been examined experimentally.
The protective effects of DS on focal ischemic brain were investigated in a mouse model.
DS stimulated nitric oxide (NO) production in human brain microvascular endothelial cells (HBMECs).
DS (10–300 μg/mL) produced a concentration-dependent relaxation in mouse aorta, which was significantly attenuated by the nitric oxide synthase (NOS) inhibitor L-NAME, suggesting that DS causes vasodilation via a NO-dependent mechanism.
DS increased resting cerebral blood flow (CBF), although it caused mild hypotension.
To investigate the effect of DS on the acute cerebral injury, C57/BL6J mice received 90 min of middle cerebral artery occlusion followed by 22.5 h of reperfusion.
DS administered 3 days before arterial occlusion significantly reduced cerebral infarct size by 53.7% compared with vehicle treatment.
However, DS did not reduce brain infarction in mice treated with the relatively specific endothelial NOS (eNOS) inhibitor, N5-(1-iminoethyl)-L-ornithine, suggesting that the neuroprotective effect of DS is primarily endothelium-dependent.
This correlated with increased phosphorylation of eNOS in the brains of DS-treated mice.
DS acutely improves CBF in eNOS-dependent vasodilation and reduces infarct size in focal cerebral ischemia.
These data provide causal evidence that DS is cerebroprotective via the eNOS-dependent production of NO, which ameliorates blood circulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Ji Hyun& Park, Sun Haeng& Kim, Young Whan& Ha, Jung Min& Bae, Sun Sik& Lee, Guem San…[et al.]. 2011. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Ji Hyun…[et al.]. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Ji Hyun& Park, Sun Haeng& Kim, Young Whan& Ha, Jung Min& Bae, Sun Sik& Lee, Guem San…[et al.]. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)