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The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms
Joint Authors
Choi, Byung Tae
Cho, Su In
Bae, Sun Sik
Ha, Jung Min
Park, Sun Haeng
Kim, Young Whan
Kim, Ji Hyun
Shin, Hwa Kyoung
Lee, Guem San
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dangkwisoo-San (DS) is an herbal extract that is widely used in traditional Korean medicine to treat traumatic ecchymosis and pain by promoting blood circulation and relieving blood stasis.
However, the effect of DS in cerebrovascular disease has not been examined experimentally.
The protective effects of DS on focal ischemic brain were investigated in a mouse model.
DS stimulated nitric oxide (NO) production in human brain microvascular endothelial cells (HBMECs).
DS (10–300 μg/mL) produced a concentration-dependent relaxation in mouse aorta, which was significantly attenuated by the nitric oxide synthase (NOS) inhibitor L-NAME, suggesting that DS causes vasodilation via a NO-dependent mechanism.
DS increased resting cerebral blood flow (CBF), although it caused mild hypotension.
To investigate the effect of DS on the acute cerebral injury, C57/BL6J mice received 90 min of middle cerebral artery occlusion followed by 22.5 h of reperfusion.
DS administered 3 days before arterial occlusion significantly reduced cerebral infarct size by 53.7% compared with vehicle treatment.
However, DS did not reduce brain infarction in mice treated with the relatively specific endothelial NOS (eNOS) inhibitor, N5-(1-iminoethyl)-L-ornithine, suggesting that the neuroprotective effect of DS is primarily endothelium-dependent.
This correlated with increased phosphorylation of eNOS in the brains of DS-treated mice.
DS acutely improves CBF in eNOS-dependent vasodilation and reduces infarct size in focal cerebral ischemia.
These data provide causal evidence that DS is cerebroprotective via the eNOS-dependent production of NO, which ameliorates blood circulation.
American Psychological Association (APA)
Kim, Ji Hyun& Park, Sun Haeng& Kim, Young Whan& Ha, Jung Min& Bae, Sun Sik& Lee, Guem San…[et al.]. 2011. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493054
Modern Language Association (MLA)
Kim, Ji Hyun…[et al.]. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493054
American Medical Association (AMA)
Kim, Ji Hyun& Park, Sun Haeng& Kim, Young Whan& Ha, Jung Min& Bae, Sun Sik& Lee, Guem San…[et al.]. The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493054