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Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter
المؤلفون المشاركون
Arbuthnot, Patrick
Mowa, Mohube Betty
Crowther, Carol
Ely, Abdullah
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Research on applying RNA interference (RNAi) to counter HBV replication has led to identification of potential therapeutic sequences.
However, before clinical application liver-specific expression and efficient delivery of these sequences remain an important objective.
We recently reported short-term inhibition of HBV replication in vivo by using helper dependent adenoviral vectors (HD Ads) expressing anti-HBV sequences from a constitutively active cytomegalovirus (CMV) promoter.
To develop the use of liver-specific transcription regulatory elements we investigated the utility of the murine transthyretin (MTTR) promoter for expression of anti-HBV primary microRNAs (pri-miRs).
HD Ads containing MTTR promoter effected superior expression of anti-HBV pri-miRs in mice compared to HD Ads containing the CMV promoter.
MTTR-containing HD Ads resulted in HBV replication knockdown of up to 94% in mice.
HD Ads expressing trimeric anti-HBV pri-miRs silenced HBV replication for 5 weeks.
We previously showed that the product of the codelivered lacZ gene induces an immune response, and the duration of HBV silencing in vivo is likely to be attenuated by this effect.
Nevertheless, expression of anti-HBV pri-miRs from MTTR promoter is well suited to countering HBV replication and development of HD Ads through attenuation of their immunostimulatory effects should advance their clinical utility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mowa, Mohube Betty& Crowther, Carol& Ely, Abdullah& Arbuthnot, Patrick. 2014. Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mowa, Mohube Betty…[et al.]. Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-493109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mowa, Mohube Betty& Crowther, Carol& Ely, Abdullah& Arbuthnot, Patrick. Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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