Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy
المؤلفون المشاركون
Meattini, Icro
Livi, Lorenzo
Simoncini, Roberta
Francolini, Giulio
Greto, Daniela
Bianchi, Simonetta
Casella, Donato
Mangoni, Monica
Nori, Jacopo
Fambrini, Massimiliano
Saieva, Calogero
Cecchini, Sara
Scotti, Vieri
Orzalesi, Lorenzo
Bonomo, Pierluigi
Di Cataldo, Vanessa
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Neoadjuvant chemotherapy (NAC) is widely used in locally advanced breast cancer (BC) treatment.
The role of postmastectomy radiotherapy (PMRT) after NAC is strongly debated.
The aim of our analysis was to identify major prognostic factors in a single-center series, with emphasis on PMRT.
From 1997 to 2011, 170 patients were treated with NAC and mastectomy at our center; 98 cases (57.6%) underwent PMRT and 72 cases (42.4%) did not receive radiation.
At a median follow-up period of 7.7 years (range 2–16) for the whole cohort, median time to locoregional recurrence (LRR) was 3.3 years (range 0.7–12.4).
The 5-year and 10-year actuarial LRR rate were 14.5% and 15.9%, respectively.
At the multivariate analysis the factors that significantly correlated with survival outcome were ≥4 positive nodes (HR 5.0, 1.51–16.52; P=0.035), extracapsular extension (HR 2.18, 1.37–3.46; P=0.009), and estrogen receptor positive disease (HR 0.57, 0.36–0.90; P=0.003).
Concerning LRR according to use of radiation, PMRT reduced LRR for patient with clinical T3 staged disease (P=0.015).
Our experience confirmed the impact of pathological nodal involvement on survival outcome.
PMRT was found to improve local control in patients presenting with clinical T3 tumors, regardless of the response to chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meattini, Icro& Cecchini, Sara& Di Cataldo, Vanessa& Saieva, Calogero& Francolini, Giulio& Scotti, Vieri…[et al.]. 2014. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meattini, Icro…[et al.]. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-493144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meattini, Icro& Cecchini, Sara& Di Cataldo, Vanessa& Saieva, Calogero& Francolini, Giulio& Scotti, Vieri…[et al.]. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر