Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy
Joint Authors
Meattini, Icro
Livi, Lorenzo
Simoncini, Roberta
Francolini, Giulio
Greto, Daniela
Bianchi, Simonetta
Casella, Donato
Mangoni, Monica
Nori, Jacopo
Fambrini, Massimiliano
Saieva, Calogero
Cecchini, Sara
Scotti, Vieri
Orzalesi, Lorenzo
Bonomo, Pierluigi
Di Cataldo, Vanessa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neoadjuvant chemotherapy (NAC) is widely used in locally advanced breast cancer (BC) treatment.
The role of postmastectomy radiotherapy (PMRT) after NAC is strongly debated.
The aim of our analysis was to identify major prognostic factors in a single-center series, with emphasis on PMRT.
From 1997 to 2011, 170 patients were treated with NAC and mastectomy at our center; 98 cases (57.6%) underwent PMRT and 72 cases (42.4%) did not receive radiation.
At a median follow-up period of 7.7 years (range 2–16) for the whole cohort, median time to locoregional recurrence (LRR) was 3.3 years (range 0.7–12.4).
The 5-year and 10-year actuarial LRR rate were 14.5% and 15.9%, respectively.
At the multivariate analysis the factors that significantly correlated with survival outcome were ≥4 positive nodes (HR 5.0, 1.51–16.52; P=0.035), extracapsular extension (HR 2.18, 1.37–3.46; P=0.009), and estrogen receptor positive disease (HR 0.57, 0.36–0.90; P=0.003).
Concerning LRR according to use of radiation, PMRT reduced LRR for patient with clinical T3 staged disease (P=0.015).
Our experience confirmed the impact of pathological nodal involvement on survival outcome.
PMRT was found to improve local control in patients presenting with clinical T3 tumors, regardless of the response to chemotherapy.
American Psychological Association (APA)
Meattini, Icro& Cecchini, Sara& Di Cataldo, Vanessa& Saieva, Calogero& Francolini, Giulio& Scotti, Vieri…[et al.]. 2014. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493144
Modern Language Association (MLA)
Meattini, Icro…[et al.]. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-493144
American Medical Association (AMA)
Meattini, Icro& Cecchini, Sara& Di Cataldo, Vanessa& Saieva, Calogero& Francolini, Giulio& Scotti, Vieri…[et al.]. Postmastectomy Radiotherapy for Locally Advanced Breast Cancer Receiving Neoadjuvant Chemotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-493144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493144