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Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation
المؤلفون المشاركون
Jiang, Chunping
Wang, Zhongxia
Ding, Yitao
Zhang, Guang
Wu, Junhua
Cao, Yin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world.
Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC.
Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34b/c T>C rs4938723 with the risk of HCC.
However the results are inconsistent and inconclusive.
In this present study, we conducted a meta-analysis to comprehensively evaluate potential associations between the two SNPs and HCC susceptibility.
Methods.
Through a systematic literature search, 8-case-control studies involving 5464 subjects were identified and included in this meta-analysis.
The association between the two common SNPs and HCC risk was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).
Our results showed no significant association between rs3746444 and susceptibility to HCC, whereas variant genotypes of rs4938723 were associated with increased HCC risk in allele frequency model and heterozygous model (C versus T, OR=1.11, 95% CI: 1.01–1.23, P=0.04; TC versus TT, OR=1.19, 95% CI: 1.03–1.37, P=0.02).
Conclusions.
The current evidence did not support association between rs3746444 and HCC risk.
SNP rs4938723 may be associated with susceptibility to HCC.
Further well-designed studies are required to clarify the relationships between the two SNPs and HCC risk.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhongxia& Wu, Junhua& Zhang, Guang& Cao, Yin& Jiang, Chunping& Ding, Yitao. 2013. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493147
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhongxia…[et al.]. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-493147
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhongxia& Wu, Junhua& Zhang, Guang& Cao, Yin& Jiang, Chunping& Ding, Yitao. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493147
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493147
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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