Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation
Joint Authors
Jiang, Chunping
Wang, Zhongxia
Ding, Yitao
Zhang, Guang
Wu, Junhua
Cao, Yin
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world.
Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC.
Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and miR-34b/c T>C rs4938723 with the risk of HCC.
However the results are inconsistent and inconclusive.
In this present study, we conducted a meta-analysis to comprehensively evaluate potential associations between the two SNPs and HCC susceptibility.
Methods.
Through a systematic literature search, 8-case-control studies involving 5464 subjects were identified and included in this meta-analysis.
The association between the two common SNPs and HCC risk was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).
Our results showed no significant association between rs3746444 and susceptibility to HCC, whereas variant genotypes of rs4938723 were associated with increased HCC risk in allele frequency model and heterozygous model (C versus T, OR=1.11, 95% CI: 1.01–1.23, P=0.04; TC versus TT, OR=1.19, 95% CI: 1.03–1.37, P=0.02).
Conclusions.
The current evidence did not support association between rs3746444 and HCC risk.
SNP rs4938723 may be associated with susceptibility to HCC.
Further well-designed studies are required to clarify the relationships between the two SNPs and HCC risk.
American Psychological Association (APA)
Wang, Zhongxia& Wu, Junhua& Zhang, Guang& Cao, Yin& Jiang, Chunping& Ding, Yitao. 2013. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493147
Modern Language Association (MLA)
Wang, Zhongxia…[et al.]. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-493147
American Medical Association (AMA)
Wang, Zhongxia& Wu, Junhua& Zhang, Guang& Cao, Yin& Jiang, Chunping& Ding, Yitao. Associations of miR-499 and miR-34bc Polymorphisms with Susceptibility to Hepatocellular Carcinoma : An Evidence-Based Evaluation. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-493147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493147