Adipose Tissue Remodeling as Homeostatic Inflammation
المؤلفون المشاركون
Itoh, Michiko
Hachiya, Rumi
Suganami, Takayoshi
Ogawa, Yoshihiro
المصدر
International Journal of Inflammation
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation.
Obese adipose tissue is characterized by dynamic changes in cellular composition and function, which may be referred to as “adipose tissue remodeling”.
Among stromal cells in the adipose tissue, infiltrated macrophages play an important role in adipose tissue inflammation and systemic insulin resistance.
We have demonstrated that a paracrine loop involving saturated fatty acids and tumor necrosis factor-α derived from adipocytes and macrophages, respectively, aggravates obesity-induced adipose tissue inflammation.
Notably, saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 complex, thereby activating macrophages.
Such a sustained interaction between endogenous ligands derived from parenchymal cells and pathogen sensors expressed in stromal immune cells should lead to chronic inflammatory responses ranging from the basal homeostatic state to diseased tissue remodeling, which may be referred to as “homeostatic inflammation”.
We, therefore, postulate that adipose tissue remodeling may represent a prototypic example of homeostatic inflammation.
Understanding the molecular mechanism underlying homeostatic inflammation may lead to the identification of novel therapeutic strategies to prevent or treat obesity-related complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Itoh, Michiko& Suganami, Takayoshi& Hachiya, Rumi& Ogawa, Yoshihiro. 2011. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Itoh, Michiko…[et al.]. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Itoh, Michiko& Suganami, Takayoshi& Hachiya, Rumi& Ogawa, Yoshihiro. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر