Adipose Tissue Remodeling as Homeostatic Inflammation
Joint Authors
Itoh, Michiko
Hachiya, Rumi
Suganami, Takayoshi
Ogawa, Yoshihiro
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation.
Obese adipose tissue is characterized by dynamic changes in cellular composition and function, which may be referred to as “adipose tissue remodeling”.
Among stromal cells in the adipose tissue, infiltrated macrophages play an important role in adipose tissue inflammation and systemic insulin resistance.
We have demonstrated that a paracrine loop involving saturated fatty acids and tumor necrosis factor-α derived from adipocytes and macrophages, respectively, aggravates obesity-induced adipose tissue inflammation.
Notably, saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 complex, thereby activating macrophages.
Such a sustained interaction between endogenous ligands derived from parenchymal cells and pathogen sensors expressed in stromal immune cells should lead to chronic inflammatory responses ranging from the basal homeostatic state to diseased tissue remodeling, which may be referred to as “homeostatic inflammation”.
We, therefore, postulate that adipose tissue remodeling may represent a prototypic example of homeostatic inflammation.
Understanding the molecular mechanism underlying homeostatic inflammation may lead to the identification of novel therapeutic strategies to prevent or treat obesity-related complications.
American Psychological Association (APA)
Itoh, Michiko& Suganami, Takayoshi& Hachiya, Rumi& Ogawa, Yoshihiro. 2011. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493292
Modern Language Association (MLA)
Itoh, Michiko…[et al.]. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493292
American Medical Association (AMA)
Itoh, Michiko& Suganami, Takayoshi& Hachiya, Rumi& Ogawa, Yoshihiro. Adipose Tissue Remodeling as Homeostatic Inflammation. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493292