Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury
المؤلفون المشاركون
Vlaar, Alexander P. J.
Schultz, Marcus J.
Roelofs, Joris J. T. H.
Lutter, R.
Juffermans, Nicole P.
Wieland, C. W.
Hofstra, J. J.
Boon, L.
Kuipers, Maria T.
Wolthuis, Esther K.
المصدر
Critical Care Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Onset of transfusion-related acute lung injury (TRALI) is suggested to be a threshold-event.
Data is lacking on the relation between titer of antibodies infused and onset of TRALI.
We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl.
Methods.
BALB/c mice were ventilated for five hours with low (7.5 ml/kg) or high (15 ml/kg) tidal volume.
After three hours of MV, TRALI was induced by infusion of 0.5 mg/kg, 2.0 mg/kg or 4.5 mg/kg MHC-I antibodies.
Control animals received vehicle.
After five hours of MV, animals were sacrificed.
Results.
MV with high tidal volumes resulted in increased levels of all markers of lung injury compared to animals ventilated with low tidal MV.
In ventilator-induced lung injury, infusion of 4.5 mg/kg of antibodies further increased pulmonary wet-to-dry ratio, pulmonary neutrophil influx and pulmonary KC levels, whereas infusion of lower dose of antibodies did not augment lung injury.
In contrast, mice ventilated with low tidal volumes did not develop lung injury, irrespective of the dose of antibody used.
Conclusions.
In the presence of injurious MV, onset of TRALI depends on the titer of antibodies infused.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vlaar, Alexander P. J.& Kuipers, Maria T.& Hofstra, J. J.& Wolthuis, Esther K.& Wieland, C. W.& Roelofs, Joris J. T. H.…[et al.]. 2012. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493294
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vlaar, Alexander P. J.…[et al.]. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493294
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vlaar, Alexander P. J.& Kuipers, Maria T.& Hofstra, J. J.& Wolthuis, Esther K.& Wieland, C. W.& Roelofs, Joris J. T. H.…[et al.]. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493294
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493294
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر