Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury
Joint Authors
Vlaar, Alexander P. J.
Schultz, Marcus J.
Roelofs, Joris J. T. H.
Lutter, R.
Juffermans, Nicole P.
Wieland, C. W.
Hofstra, J. J.
Boon, L.
Kuipers, Maria T.
Wolthuis, Esther K.
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
Onset of transfusion-related acute lung injury (TRALI) is suggested to be a threshold-event.
Data is lacking on the relation between titer of antibodies infused and onset of TRALI.
We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl.
Methods.
BALB/c mice were ventilated for five hours with low (7.5 ml/kg) or high (15 ml/kg) tidal volume.
After three hours of MV, TRALI was induced by infusion of 0.5 mg/kg, 2.0 mg/kg or 4.5 mg/kg MHC-I antibodies.
Control animals received vehicle.
After five hours of MV, animals were sacrificed.
Results.
MV with high tidal volumes resulted in increased levels of all markers of lung injury compared to animals ventilated with low tidal MV.
In ventilator-induced lung injury, infusion of 4.5 mg/kg of antibodies further increased pulmonary wet-to-dry ratio, pulmonary neutrophil influx and pulmonary KC levels, whereas infusion of lower dose of antibodies did not augment lung injury.
In contrast, mice ventilated with low tidal volumes did not develop lung injury, irrespective of the dose of antibody used.
Conclusions.
In the presence of injurious MV, onset of TRALI depends on the titer of antibodies infused.
American Psychological Association (APA)
Vlaar, Alexander P. J.& Kuipers, Maria T.& Hofstra, J. J.& Wolthuis, Esther K.& Wieland, C. W.& Roelofs, Joris J. T. H.…[et al.]. 2012. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493294
Modern Language Association (MLA)
Vlaar, Alexander P. J.…[et al.]. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493294
American Medical Association (AMA)
Vlaar, Alexander P. J.& Kuipers, Maria T.& Hofstra, J. J.& Wolthuis, Esther K.& Wieland, C. W.& Roelofs, Joris J. T. H.…[et al.]. Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493294