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Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats
المؤلفون المشاركون
Parlakpınar, Hakan
Gurlek, Ali
Bay-Karabulut, Aysun
Kirimlioglu, Hale
Ozturk, Ayse
Fırat, Cemal
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Random flaps in DM patients have poor reliability for wound coverage, and flap loss remains a complex challenge.
The protective effects of aminoguanidine (AG) administration on the survival of dorsal random flaps and oxidative stress were studied in diabetic rats.
Two months after the onset of DM, dorsal McFarlane flaps were raised.
Forty rats were divided into four groups: (1) control, (2) AG, (3) DM, and (4) DM + AG groups.
Flap viability, determined with the planimetric method, and free-radical measurements were investigated.
In addition, HbA1c and blood glucose levels, body weight measurements, and histopathological examinations were evaluated.
The mean flap necrotic areas (%) in Groups I to IV were 50.9 ± 13.0, 32.9 ± 12.5, 65.2 ± 11.5, and 43.5 ± 14.7, respectively.
The malondialdehyde (MDA) and nitric oxide (NO) levels were higher in the DM group than in the nondiabetic group, while the reduced glutathione (GSH) levels and superoxide dismutase (SOD) activity were reduced as a result of flap injury.
In the diabetic and nondiabetic groups, AG administration significantly reduced the MDA and NO levels and significantly increased GSH content and SOD enzyme activity.
We concluded that AG plays an important role in preventing random pattern flap necrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ozturk, Ayse& Fırat, Cemal& Parlakpınar, Hakan& Bay-Karabulut, Aysun& Kirimlioglu, Hale& Gurlek, Ali. 2012. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ozturk, Ayse…[et al.]. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ozturk, Ayse& Fırat, Cemal& Parlakpınar, Hakan& Bay-Karabulut, Aysun& Kirimlioglu, Hale& Gurlek, Ali. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493311
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