Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats
Joint Authors
Parlakpınar, Hakan
Gurlek, Ali
Bay-Karabulut, Aysun
Kirimlioglu, Hale
Ozturk, Ayse
Fırat, Cemal
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Random flaps in DM patients have poor reliability for wound coverage, and flap loss remains a complex challenge.
The protective effects of aminoguanidine (AG) administration on the survival of dorsal random flaps and oxidative stress were studied in diabetic rats.
Two months after the onset of DM, dorsal McFarlane flaps were raised.
Forty rats were divided into four groups: (1) control, (2) AG, (3) DM, and (4) DM + AG groups.
Flap viability, determined with the planimetric method, and free-radical measurements were investigated.
In addition, HbA1c and blood glucose levels, body weight measurements, and histopathological examinations were evaluated.
The mean flap necrotic areas (%) in Groups I to IV were 50.9 ± 13.0, 32.9 ± 12.5, 65.2 ± 11.5, and 43.5 ± 14.7, respectively.
The malondialdehyde (MDA) and nitric oxide (NO) levels were higher in the DM group than in the nondiabetic group, while the reduced glutathione (GSH) levels and superoxide dismutase (SOD) activity were reduced as a result of flap injury.
In the diabetic and nondiabetic groups, AG administration significantly reduced the MDA and NO levels and significantly increased GSH content and SOD enzyme activity.
We concluded that AG plays an important role in preventing random pattern flap necrosis.
American Psychological Association (APA)
Ozturk, Ayse& Fırat, Cemal& Parlakpınar, Hakan& Bay-Karabulut, Aysun& Kirimlioglu, Hale& Gurlek, Ali. 2012. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493311
Modern Language Association (MLA)
Ozturk, Ayse…[et al.]. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-493311
American Medical Association (AMA)
Ozturk, Ayse& Fırat, Cemal& Parlakpınar, Hakan& Bay-Karabulut, Aysun& Kirimlioglu, Hale& Gurlek, Ali. Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-493311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493311