Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease : Towards a Multi-Biomarker Approach

الملخص EN

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls.

All biomarkers were analyzed again after 6 months.

Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction.

Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls.

After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls.

Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases.

In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.