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Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy
المؤلفون المشاركون
Zhang, Liping
Shi, Donghong
Lu, Guang Ming
Pan, Zhiying
Liang, Xue
Li, Qiang
Zheng, Gang
Zhang, Long Jiang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Minimal hepatic encephalopathy (MHE) is associated with changes in functional connectivity.
To investigate the patterns of modular changes of the functional connectivity in the progression of MHE, resting-state functional magnetic resonance imaging was acquired in 24 MHE patients, 31 cirrhotic patients without minimal hepatic encephalopathy (non-HE), and 38 healthy controls.
Newman’s metric, the modularity Q value, was maximized and compared in three groups.
Topological roles with the progression of MHE were illustrated by intra- and intermodular connectivity changes.
Results showed that the Q value of MHE patients was significantly lower than that of controls P<0.01 rather than that of non-HE patients P>0.05, which was correlated with neuropsychological test scores rather than the ammonia level and Child-Pugh score.
Less intrasubcortical connections and more isolated subcortical modules were found with the progression of MHE.
The non-HE patients had the same numbers of connect nodes as controls and had more hubs compared with MHE patients and healthy controls.
Our findings supported that both intra- and intermodular connectivity, especially those related to subcortical regions, were continuously impaired in cirrhotic patients.
The adjustments of hubs and connector nodes in non-HE patients could be a compensation for the decreased modularity in their functional connectivity networks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Gang& Zhang, Liping& Zhang, Long Jiang& Li, Qiang& Pan, Zhiying& Liang, Xue…[et al.]. 2014. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Gang…[et al.]. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-493849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Gang& Zhang, Liping& Zhang, Long Jiang& Li, Qiang& Pan, Zhiying& Liang, Xue…[et al.]. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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