Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy

Joint Authors

Zhang, Liping
Shi, Donghong
Lu, Guang Ming
Pan, Zhiying
Liang, Xue
Li, Qiang
Zheng, Gang
Zhang, Long Jiang

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-06-05

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Minimal hepatic encephalopathy (MHE) is associated with changes in functional connectivity.

To investigate the patterns of modular changes of the functional connectivity in the progression of MHE, resting-state functional magnetic resonance imaging was acquired in 24 MHE patients, 31 cirrhotic patients without minimal hepatic encephalopathy (non-HE), and 38 healthy controls.

Newman’s metric, the modularity Q value, was maximized and compared in three groups.

Topological roles with the progression of MHE were illustrated by intra- and intermodular connectivity changes.

Results showed that the Q value of MHE patients was significantly lower than that of controls P<0.01 rather than that of non-HE patients P>0.05, which was correlated with neuropsychological test scores rather than the ammonia level and Child-Pugh score.

Less intrasubcortical connections and more isolated subcortical modules were found with the progression of MHE.

The non-HE patients had the same numbers of connect nodes as controls and had more hubs compared with MHE patients and healthy controls.

Our findings supported that both intra- and intermodular connectivity, especially those related to subcortical regions, were continuously impaired in cirrhotic patients.

The adjustments of hubs and connector nodes in non-HE patients could be a compensation for the decreased modularity in their functional connectivity networks.

American Psychological Association (APA)

Zheng, Gang& Zhang, Liping& Zhang, Long Jiang& Li, Qiang& Pan, Zhiying& Liang, Xue…[et al.]. 2014. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493849

Modern Language Association (MLA)

Zheng, Gang…[et al.]. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-493849

American Medical Association (AMA)

Zheng, Gang& Zhang, Liping& Zhang, Long Jiang& Li, Qiang& Pan, Zhiying& Liang, Xue…[et al.]. Altered Modular Organization of Functional Connectivity Networks in Cirrhotic Patients without Overt Hepatic Encephalopathy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-493849

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-493849