![](/images/graphics-bg.png)
Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine
المؤلفون المشاركون
Frank, Robin R.
Venugopal, Parameswaran
Paganessi, Laura A.
Jagan, Sucheta
Larson, Melissa
Christopherson, Kent W.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Achieving improvements in survival and reducing relapse remains a challenge in acute myelogenous leukemia (AML) patients.
This study evaluated the in vitro efficacy of the active form of novel agent sapacitabine, CNDAC, compared to current chemotherapeutic drugs Ara-C and mitoxantrone using two AML cell lines, HL-60 (promyelocytic) and THP-1 (monocytic), as well as bone marrow (BM) and peripheral blood (PB) cells collected from AML patients.
Cell lines were exposed to compound for 3–6 days and primary cells for 4 days.
The viability of primary cells was additionally evaluated 3, 7, and 31 days after removal of tested compound to determine the durability of the response.
Our studies indicate that CNDAC and mitoxantrone have a greater impact on viability than ara-C in primary AML cells and AML cell lines.
CNDAC is more effective at reducing viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line, which is defined as displaying resistance to ara-C.
As sapacitabine has shown in vivo activity at clinically achievable doses, future studies are warranted to assess the potential for combining it with ara-C and/or mitoxantrone, with an emphasis on cells and patients insensitive to ara-C treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jagan, Sucheta& Paganessi, Laura A.& Frank, Robin R.& Venugopal, Parameswaran& Larson, Melissa& Christopherson, Kent W.. 2012. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jagan, Sucheta…[et al.]. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-493860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jagan, Sucheta& Paganessi, Laura A.& Frank, Robin R.& Venugopal, Parameswaran& Larson, Melissa& Christopherson, Kent W.. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)