Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine
Joint Authors
Frank, Robin R.
Venugopal, Parameswaran
Paganessi, Laura A.
Jagan, Sucheta
Larson, Melissa
Christopherson, Kent W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Achieving improvements in survival and reducing relapse remains a challenge in acute myelogenous leukemia (AML) patients.
This study evaluated the in vitro efficacy of the active form of novel agent sapacitabine, CNDAC, compared to current chemotherapeutic drugs Ara-C and mitoxantrone using two AML cell lines, HL-60 (promyelocytic) and THP-1 (monocytic), as well as bone marrow (BM) and peripheral blood (PB) cells collected from AML patients.
Cell lines were exposed to compound for 3–6 days and primary cells for 4 days.
The viability of primary cells was additionally evaluated 3, 7, and 31 days after removal of tested compound to determine the durability of the response.
Our studies indicate that CNDAC and mitoxantrone have a greater impact on viability than ara-C in primary AML cells and AML cell lines.
CNDAC is more effective at reducing viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line, which is defined as displaying resistance to ara-C.
As sapacitabine has shown in vivo activity at clinically achievable doses, future studies are warranted to assess the potential for combining it with ara-C and/or mitoxantrone, with an emphasis on cells and patients insensitive to ara-C treatment.
American Psychological Association (APA)
Jagan, Sucheta& Paganessi, Laura A.& Frank, Robin R.& Venugopal, Parameswaran& Larson, Melissa& Christopherson, Kent W.. 2012. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493860
Modern Language Association (MLA)
Jagan, Sucheta…[et al.]. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-493860
American Medical Association (AMA)
Jagan, Sucheta& Paganessi, Laura A.& Frank, Robin R.& Venugopal, Parameswaran& Larson, Melissa& Christopherson, Kent W.. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-493860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493860