Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury
المؤلفون المشاركون
Yang, Xiao-Yuan
Han, Jing-Yan
Wei, Xiao-Hong
Zhao, Na
Liu, Yu-Ying
Sun, Kai
Fan, Jing-Yu
Chang, Xin
Hu, Bai-He
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris.
Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion- (I/R-) induced myocardial injury and cardiac microcirculatory disturbance.
The present study aimed to investigate the effect of CP at low dosage in a multiple dosing manner and to uncover the mechanism of antioxidative activity of CP.
Male Sprague-Dawley rats were subjected to left anterior descending artery occlusion for 30 min followed by 60 min reperfusion.
CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R.
Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress.
CP dramatically inhibited I/R-induced nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase subunit gp91phox expression and p67phox and p47phox translocation from cytosol to cell membrane.
Translocation of cytosolic subunits to membrane is required for the activation of NADPH oxidase.
These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiao-Yuan& Zhao, Na& Liu, Yu-Ying& Hu, Bai-He& Sun, Kai& Chang, Xin…[et al.]. 2013. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-493881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiao-Yuan…[et al.]. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-493881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiao-Yuan& Zhao, Na& Liu, Yu-Ying& Hu, Bai-He& Sun, Kai& Chang, Xin…[et al.]. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-493881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-493881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر