Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury
Joint Authors
Yang, Xiao-Yuan
Han, Jing-Yan
Wei, Xiao-Hong
Zhao, Na
Liu, Yu-Ying
Sun, Kai
Fan, Jing-Yu
Chang, Xin
Hu, Bai-He
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris.
Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion- (I/R-) induced myocardial injury and cardiac microcirculatory disturbance.
The present study aimed to investigate the effect of CP at low dosage in a multiple dosing manner and to uncover the mechanism of antioxidative activity of CP.
Male Sprague-Dawley rats were subjected to left anterior descending artery occlusion for 30 min followed by 60 min reperfusion.
CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R.
Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress.
CP dramatically inhibited I/R-induced nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase subunit gp91phox expression and p67phox and p47phox translocation from cytosol to cell membrane.
Translocation of cytosolic subunits to membrane is required for the activation of NADPH oxidase.
These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation.
American Psychological Association (APA)
Yang, Xiao-Yuan& Zhao, Na& Liu, Yu-Ying& Hu, Bai-He& Sun, Kai& Chang, Xin…[et al.]. 2013. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-493881
Modern Language Association (MLA)
Yang, Xiao-Yuan…[et al.]. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-493881
American Medical Association (AMA)
Yang, Xiao-Yuan& Zhao, Na& Liu, Yu-Ying& Hu, Bai-He& Sun, Kai& Chang, Xin…[et al.]. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-493881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493881