Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations

المؤلفون المشاركون

Revanasiddappa, Hosakere Doddarevanna
Deepakumari, Hemavathi Nagaraju

المصدر

ISRN Spectroscopy

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-11-27

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الفيزياء

الملخص EN

Three simple, rapid, precise, sensitive, and accurate visible spectrophotometric methods (A, B, and C) are described for the estimation of flutamide in both pure and pharmaceutical preparations.

They are based on the diazotization of reduced flutamide (FA) with nitrous acid followed by coupling with acetyl acetone (method A), citrazinic acid (method B), and 8-hydroxyquinoline (method C) to form colored azo dyes, exhibiting absorption maxima (λmax) at 410, 440 and 500 nm, for methods A, B, and C, respectively.

Linear concentration range was of 0.5–12, 0.5–10, and 0.3–10 μg/mL for methods A, B, and C, respectively, and the corresponding molar absorptivity values are 2.23×104, 2.04×104, and 1.35×104 L mol−1 cm−1.

The correlation coefficients for FA are 0.9988, 0.9976, and 0.9975 for methods A, B, and C, respectively.

All variables were optimized, and the results were statistically compared with those of a literature method by employing Student’s t-test and F-test.

No interference was observed from common adjuvants normally added to the tablets.

The relative standard deviations (n=5) for FA in all the three methods in the tablets are always less than 3%.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. 2012. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493947

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493947

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493947

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-493947