Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations
Joint Authors
Revanasiddappa, Hosakere Doddarevanna
Deepakumari, Hemavathi Nagaraju
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Three simple, rapid, precise, sensitive, and accurate visible spectrophotometric methods (A, B, and C) are described for the estimation of flutamide in both pure and pharmaceutical preparations.
They are based on the diazotization of reduced flutamide (FA) with nitrous acid followed by coupling with acetyl acetone (method A), citrazinic acid (method B), and 8-hydroxyquinoline (method C) to form colored azo dyes, exhibiting absorption maxima (λmax) at 410, 440 and 500 nm, for methods A, B, and C, respectively.
Linear concentration range was of 0.5–12, 0.5–10, and 0.3–10 μg/mL for methods A, B, and C, respectively, and the corresponding molar absorptivity values are 2.23×104, 2.04×104, and 1.35×104 L mol−1 cm−1.
The correlation coefficients for FA are 0.9988, 0.9976, and 0.9975 for methods A, B, and C, respectively.
All variables were optimized, and the results were statistically compared with those of a literature method by employing Student’s t-test and F-test.
No interference was observed from common adjuvants normally added to the tablets.
The relative standard deviations (n=5) for FA in all the three methods in the tablets are always less than 3%.
American Psychological Association (APA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. 2012. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493947
Modern Language Association (MLA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-493947
American Medical Association (AMA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Spectrophotometric Estimation of Flutamide in Pure and in Pharmaceutical Preparations. ISRN Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-493947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493947