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Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity
المؤلفون المشاركون
Dong, Hang
Yu, Zhi-Ling
Ko, Kam Ming
Xiang, Chun-Jing
Pan, Si-Yuan
Fong, Wang-Fun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Effects of the ethanol extract of Fructus Schisandrae (EtFSC) on serum and liver lipid contents were investigated in mice fed with high fat/cholesterol (HFC) diet for 8 or 15 days.
The induction of hypercholesterolemia by HFC diet caused significant increases in serum and hepatic total cholesterol (TC) levels (up to 62% and 165%, resp.) and hepatic triglyceride (TG) levels (up to 528%) in mice.
EtFSC treatment (1 or 5 g/kg/day for 7 days; from Day 1 to 7 or from Day 8 to 14, i.g.) significantly decreased the hepatic TG level (down to 35%) and slightly increased the hepatic index (by 8%) in hypercholesterolemic mice.
Whereas fenofibrate treatment (0.1 g/kg/day for 7 days, i.g.) significantly lowered the hepatic TG level (by 61%), it elevated the hepatic index (by 77%) in hypercholesterolemic mice.
Acute toxicity test showed that EtFSC was relatively non-toxic, with an LD50 value of 35.63 ± 6.46 g/kg in mice.
The results indicate that EtFSC treatment can invariably decrease hepatic TG in hypercholesterolemic mice, as assessed by both preventive and therapeutic protocols, suggesting its potential use for fatty liver treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Si-Yuan& Yu, Zhi-Ling& Dong, Hang& Xiang, Chun-Jing& Fong, Wang-Fun& Ko, Kam Ming. 2011. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494021
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Si-Yuan…[et al.]. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494021
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Si-Yuan& Yu, Zhi-Ling& Dong, Hang& Xiang, Chun-Jing& Fong, Wang-Fun& Ko, Kam Ming. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494021
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494021
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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