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Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity
Joint Authors
Dong, Hang
Yu, Zhi-Ling
Ko, Kam Ming
Xiang, Chun-Jing
Pan, Si-Yuan
Fong, Wang-Fun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Effects of the ethanol extract of Fructus Schisandrae (EtFSC) on serum and liver lipid contents were investigated in mice fed with high fat/cholesterol (HFC) diet for 8 or 15 days.
The induction of hypercholesterolemia by HFC diet caused significant increases in serum and hepatic total cholesterol (TC) levels (up to 62% and 165%, resp.) and hepatic triglyceride (TG) levels (up to 528%) in mice.
EtFSC treatment (1 or 5 g/kg/day for 7 days; from Day 1 to 7 or from Day 8 to 14, i.g.) significantly decreased the hepatic TG level (down to 35%) and slightly increased the hepatic index (by 8%) in hypercholesterolemic mice.
Whereas fenofibrate treatment (0.1 g/kg/day for 7 days, i.g.) significantly lowered the hepatic TG level (by 61%), it elevated the hepatic index (by 77%) in hypercholesterolemic mice.
Acute toxicity test showed that EtFSC was relatively non-toxic, with an LD50 value of 35.63 ± 6.46 g/kg in mice.
The results indicate that EtFSC treatment can invariably decrease hepatic TG in hypercholesterolemic mice, as assessed by both preventive and therapeutic protocols, suggesting its potential use for fatty liver treatment.
American Psychological Association (APA)
Pan, Si-Yuan& Yu, Zhi-Ling& Dong, Hang& Xiang, Chun-Jing& Fong, Wang-Fun& Ko, Kam Ming. 2011. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494021
Modern Language Association (MLA)
Pan, Si-Yuan…[et al.]. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494021
American Medical Association (AMA)
Pan, Si-Yuan& Yu, Zhi-Ling& Dong, Hang& Xiang, Chun-Jing& Fong, Wang-Fun& Ko, Kam Ming. Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High FatCholesterol Diet, with Attention to Acute Toxicity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494021