Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans
المؤلفون المشاركون
Acheampong, Joseph
Huang, Hanxia
Adebamowo, C.
Balogun, Williams
Adeleye, Jokotade
Rotimi, Charles N.
Zhou, Jie
Agyenim-Boateng, Kofi
Amoah, Albert
Okafor, Godfrey
Adeyemo, Adebowale
Doumatey, Ayo P.
Fasanmade, Olufemi
Oli, Johnnie
Eghan, Benjamin A.
Johnson, Thomas
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction.
However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular.
Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans.
Total adiponectin was measured in 792 participants.
MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function.
Linear and logistic regression models were used to determine the relationship between adiponectin and renal function.
Adiponectin showed an inverse relationship with eGFR in univariate (BetaMDRD=-0.18, BetaCG=-0.26) and multivariate (BetaMDRD=-0.10, BetaCG=-0.09) regression analyses.
The multivariate models that included age, sex, BMI, hypertension, smoking, HDL-C, LDL-C, triglycerides, and adiponectin explained 30% and 55.6% of the variance in GFR estimated by MDRD and CG methods, respectively.
Adiponectin was also a strong predictor of moderate chronic kidney disease (defined as eGFR < 60 mL/min/1.73 m2).
We demonstrate that adiponectin is associated with renal function in nondiabetic West Africans.
The observed relationship is independent of age and serum lipids.
Our findings suggest that adiponectin may have clinical utility as a biomarker of renal function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Doumatey, Ayo P.& Zhou, Jie& Huang, Hanxia& Adeleye, Jokotade& Balogun, Williams& Fasanmade, Olufemi…[et al.]. 2012. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494164
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Doumatey, Ayo P.…[et al.]. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-494164
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Doumatey, Ayo P.& Zhou, Jie& Huang, Hanxia& Adeleye, Jokotade& Balogun, Williams& Fasanmade, Olufemi…[et al.]. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494164
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494164
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر