Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans
Joint Authors
Acheampong, Joseph
Huang, Hanxia
Adebamowo, C.
Balogun, Williams
Adeleye, Jokotade
Rotimi, Charles N.
Zhou, Jie
Agyenim-Boateng, Kofi
Amoah, Albert
Okafor, Godfrey
Adeyemo, Adebowale
Doumatey, Ayo P.
Fasanmade, Olufemi
Oli, Johnnie
Eghan, Benjamin A.
Johnson, Thomas
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction.
However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in general and in African populations in particular.
Hence, we designed this study to evaluate the relationship between adiponectin and renal function in a large group of nondiabetic West Africans.
Total adiponectin was measured in 792 participants.
MDRD and Cockroft-Gault (CG-) estimated GFR were used as indices of renal function.
Linear and logistic regression models were used to determine the relationship between adiponectin and renal function.
Adiponectin showed an inverse relationship with eGFR in univariate (BetaMDRD=-0.18, BetaCG=-0.26) and multivariate (BetaMDRD=-0.10, BetaCG=-0.09) regression analyses.
The multivariate models that included age, sex, BMI, hypertension, smoking, HDL-C, LDL-C, triglycerides, and adiponectin explained 30% and 55.6% of the variance in GFR estimated by MDRD and CG methods, respectively.
Adiponectin was also a strong predictor of moderate chronic kidney disease (defined as eGFR < 60 mL/min/1.73 m2).
We demonstrate that adiponectin is associated with renal function in nondiabetic West Africans.
The observed relationship is independent of age and serum lipids.
Our findings suggest that adiponectin may have clinical utility as a biomarker of renal function.
American Psychological Association (APA)
Doumatey, Ayo P.& Zhou, Jie& Huang, Hanxia& Adeleye, Jokotade& Balogun, Williams& Fasanmade, Olufemi…[et al.]. 2012. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494164
Modern Language Association (MLA)
Doumatey, Ayo P.…[et al.]. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-494164
American Medical Association (AMA)
Doumatey, Ayo P.& Zhou, Jie& Huang, Hanxia& Adeleye, Jokotade& Balogun, Williams& Fasanmade, Olufemi…[et al.]. Circulating Adiponectin Is Associated with Renal Function Independent of Age and Serum Lipids in West Africans. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-494164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494164