A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula
المؤلفون المشاركون
Gao, Yibo
Lu, Peng
Yang, Hongjun
Liu, Xi
Tang, Shihuan
Zhang, Fangbo
Wang, Yanping
Song, Jianglong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
At the molecular level, it is acknowledged that a TCM formula is often a complex system, which challenges researchers to fully understand its underlying pharmacological action.
However, module detection technique developed from complex network provides new insight into systematic investigation of the mode of action of a TCM formula from the molecule perspective.
We here proposed a computational approach integrating the module detection technique into a 2-class heterogeneous network (2-HN) which models the complex pharmacological system of a TCM formula.
This approach takes three steps: construction of a 2-HN, identification of primary pharmacological units, and pathway analysis.
We employed this approach to study Shu-feng-jie-du (SHU) formula, which aimed at discovering its molecular mechanism in defending against influenza infection.
Actually, four primary pharmacological units were identified from the 2-HN for SHU formula and further analysis revealed numbers of biological pathways modulated by the four pharmacological units.
24 out of 40 enriched pathways that were ranked in top 10 corresponding to each of the four pharmacological units were found to be involved in the process of influenza infection.
Therefore, this approach is capable of uncovering the mode of action underlying a TCM formula via module analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Jianglong& Zhang, Fangbo& Tang, Shihuan& Liu, Xi& Gao, Yibo& Lu, Peng…[et al.]. 2013. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-494201
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Jianglong…[et al.]. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-494201
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Jianglong& Zhang, Fangbo& Tang, Shihuan& Liu, Xi& Gao, Yibo& Lu, Peng…[et al.]. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-494201
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494201
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر