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A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula
Joint Authors
Gao, Yibo
Lu, Peng
Yang, Hongjun
Liu, Xi
Tang, Shihuan
Zhang, Fangbo
Wang, Yanping
Song, Jianglong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
At the molecular level, it is acknowledged that a TCM formula is often a complex system, which challenges researchers to fully understand its underlying pharmacological action.
However, module detection technique developed from complex network provides new insight into systematic investigation of the mode of action of a TCM formula from the molecule perspective.
We here proposed a computational approach integrating the module detection technique into a 2-class heterogeneous network (2-HN) which models the complex pharmacological system of a TCM formula.
This approach takes three steps: construction of a 2-HN, identification of primary pharmacological units, and pathway analysis.
We employed this approach to study Shu-feng-jie-du (SHU) formula, which aimed at discovering its molecular mechanism in defending against influenza infection.
Actually, four primary pharmacological units were identified from the 2-HN for SHU formula and further analysis revealed numbers of biological pathways modulated by the four pharmacological units.
24 out of 40 enriched pathways that were ranked in top 10 corresponding to each of the four pharmacological units were found to be involved in the process of influenza infection.
Therefore, this approach is capable of uncovering the mode of action underlying a TCM formula via module analysis.
American Psychological Association (APA)
Song, Jianglong& Zhang, Fangbo& Tang, Shihuan& Liu, Xi& Gao, Yibo& Lu, Peng…[et al.]. 2013. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-494201
Modern Language Association (MLA)
Song, Jianglong…[et al.]. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-494201
American Medical Association (AMA)
Song, Jianglong& Zhang, Fangbo& Tang, Shihuan& Liu, Xi& Gao, Yibo& Lu, Peng…[et al.]. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula : A Trial on Shu-feng-jie-du Formula. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-494201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494201