Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle
المؤلفون المشاركون
Liang, Fengxia
Tsuda, Shinichi
Wang, Hua
Chen, Rui
Nishizawa, Makoto
Nakagawa, Atsushi
Koya, Daisuke
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Electroacupuncture (EA) has been observed to reduce insulin resistance in obesity and diabetes.
However, the biochemical mechanism underlying this effect remains unclear.
This study investigated the effects of low-frequency EA on metabolic action in genetically obese and type 2 diabetic db/db mice.
Nine-week-old db/m and db/db mice were randomly divided into four groups, namely, db/m, db/m + EA, db/db, and db/db + EA.
db/m + EA and db/db + EA mice received 3-Hz electroacupuncture five times weekly for eight consecutive weeks.
In db/db mice, EA tempered the increase in fasting blood glucose, food intake, and body mass and maintained insulin levels.
In EA-treated db/db mice, improved insulin sensitivity was established through intraperitoneal insulin tolerance test.
EA was likewise observed to decrease free fatty acid levels in db/db mice; it increased protein expression in skeletal muscle Sirtuin 1 (SIRT1) and induced gene expression of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX).
These results indicated that EA offers a beneficial effect on insulin resistance in obese and diabetic db/db mice, at least partly, via stimulation of SIRT1/PGC-1α, thus resulting in improved insulin signal.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Fengxia& Chen, Rui& Nakagawa, Atsushi& Nishizawa, Makoto& Tsuda, Shinichi& Wang, Hua…[et al.]. 2010. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Fengxia…[et al.]. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-494480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Fengxia& Chen, Rui& Nakagawa, Atsushi& Nishizawa, Makoto& Tsuda, Shinichi& Wang, Hua…[et al.]. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر