Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle
Joint Authors
Liang, Fengxia
Tsuda, Shinichi
Wang, Hua
Chen, Rui
Nishizawa, Makoto
Nakagawa, Atsushi
Koya, Daisuke
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Electroacupuncture (EA) has been observed to reduce insulin resistance in obesity and diabetes.
However, the biochemical mechanism underlying this effect remains unclear.
This study investigated the effects of low-frequency EA on metabolic action in genetically obese and type 2 diabetic db/db mice.
Nine-week-old db/m and db/db mice were randomly divided into four groups, namely, db/m, db/m + EA, db/db, and db/db + EA.
db/m + EA and db/db + EA mice received 3-Hz electroacupuncture five times weekly for eight consecutive weeks.
In db/db mice, EA tempered the increase in fasting blood glucose, food intake, and body mass and maintained insulin levels.
In EA-treated db/db mice, improved insulin sensitivity was established through intraperitoneal insulin tolerance test.
EA was likewise observed to decrease free fatty acid levels in db/db mice; it increased protein expression in skeletal muscle Sirtuin 1 (SIRT1) and induced gene expression of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear respiratory factor 1 (NRF1), and acyl-CoA oxidase (ACOX).
These results indicated that EA offers a beneficial effect on insulin resistance in obese and diabetic db/db mice, at least partly, via stimulation of SIRT1/PGC-1α, thus resulting in improved insulin signal.
American Psychological Association (APA)
Liang, Fengxia& Chen, Rui& Nakagawa, Atsushi& Nishizawa, Makoto& Tsuda, Shinichi& Wang, Hua…[et al.]. 2010. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494480
Modern Language Association (MLA)
Liang, Fengxia…[et al.]. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-494480
American Medical Association (AMA)
Liang, Fengxia& Chen, Rui& Nakagawa, Atsushi& Nishizawa, Makoto& Tsuda, Shinichi& Wang, Hua…[et al.]. Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1PGC-1α in Skeletal Muscle. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-494480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494480