Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats
المؤلفون المشاركون
El-Moselhy, M. A.
Abdel-Hamid, N. M.
El-Baz, A.
المصدر
International Journal of Hepatology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Extensive efforts are exerted looking for safe and effective chemotherapy for hepatocellular carcinoma (HCC).
Specific and sensitive early biomarkers for HCC still in query.
Present work to study proteolytic activity and lysosomal membrane integrity by hepatocarcinogen, trichloroacetic acid (TCA), in Wistar rats against aqueous olive leaf extract (AOLE).TCA showed neoplastic changes as oval- or irregular-shaped hepatocytes and transformed, vesiculated, and binucleated liver cells.
The nuclei were pleomorphic and hyperchromatic.
These changes were considerably reduced by AOLE.
The results added, probably for the first time, that TCA-induced HCC through disruption of hepatocellular proteolytic enzymes as upregulation of papain, free cathepsin-D and nonsignificant destabilization of lysosomal membrane integrity, a prerequisite for cancer invasion and metastasis.
AOLE introduced a promising therapeutic value in liver cancer, mostly through elevating lysosomal membrane integrity.
The study substantiated four main points: (1) the usefulness of proteolysis and lysosomalmembrane integrity in early prediction of HCC.
(2) TCA carcinogenesis is possibly mediated by lysosomal membrane destabilization, through cathepsin-D disruption, which could be reversed by AOLE administration.
(3) A new strategy for management of HCC, using dietary olive leaf system may be a helpful phytotherapeutic trend.
(4) A prospective study on serum proteolytic enzyme activity may introduce novel diagnostic tools.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdel-Hamid, N. M.& El-Moselhy, M. A.& El-Baz, A.. 2010. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdel-Hamid, N. M.…[et al.]. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdel-Hamid, N. M.& El-Moselhy, M. A.& El-Baz, A.. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر