Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats
Joint Authors
El-Moselhy, M. A.
Abdel-Hamid, N. M.
El-Baz, A.
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Extensive efforts are exerted looking for safe and effective chemotherapy for hepatocellular carcinoma (HCC).
Specific and sensitive early biomarkers for HCC still in query.
Present work to study proteolytic activity and lysosomal membrane integrity by hepatocarcinogen, trichloroacetic acid (TCA), in Wistar rats against aqueous olive leaf extract (AOLE).TCA showed neoplastic changes as oval- or irregular-shaped hepatocytes and transformed, vesiculated, and binucleated liver cells.
The nuclei were pleomorphic and hyperchromatic.
These changes were considerably reduced by AOLE.
The results added, probably for the first time, that TCA-induced HCC through disruption of hepatocellular proteolytic enzymes as upregulation of papain, free cathepsin-D and nonsignificant destabilization of lysosomal membrane integrity, a prerequisite for cancer invasion and metastasis.
AOLE introduced a promising therapeutic value in liver cancer, mostly through elevating lysosomal membrane integrity.
The study substantiated four main points: (1) the usefulness of proteolysis and lysosomalmembrane integrity in early prediction of HCC.
(2) TCA carcinogenesis is possibly mediated by lysosomal membrane destabilization, through cathepsin-D disruption, which could be reversed by AOLE administration.
(3) A new strategy for management of HCC, using dietary olive leaf system may be a helpful phytotherapeutic trend.
(4) A prospective study on serum proteolytic enzyme activity may introduce novel diagnostic tools.
American Psychological Association (APA)
Abdel-Hamid, N. M.& El-Moselhy, M. A.& El-Baz, A.. 2010. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494618
Modern Language Association (MLA)
Abdel-Hamid, N. M.…[et al.]. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-494618
American Medical Association (AMA)
Abdel-Hamid, N. M.& El-Moselhy, M. A.& El-Baz, A.. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International Journal of Hepatology. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-494618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494618