Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68

المؤلفون المشاركون

Hess, Michael
Nolte, Ingo
Gentschev, Ivaylo
Donat, Ulrike
Ehrig, Klaas
Chen, Nanhai G.
Yu, Yong A.
Bullerdiek, Joern
Szalay, Aladar A.
Zhang, Qian
Stritzker, Jochen
Rudolph, Stephan

المصدر

Journal of Oncology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-06-23

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment.

Therefore, there is an urgent need to identify novel agents for therapy of this disease.

Recently, we reported that the oncolytic vaccinia virus GLV-1h68 could be a useful tool for therapy of canine mammary adenoma in vivo.

In this study we analyzed the therapeutic effect of GLV-1h68 against canine mammary carcinoma.

Cell culture data demonstrated that GLV-1h68 efficiently infected and destroyed cells of the mammary carcinoma cell line MTH52c.

Furthermore, after systemic administration, this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice.

Finally, infection with GLV-1h68 led to strong inflammatory and oncolytic effects resulting in significant growth inhibition of the tumors.

In summary, the data showed that the GLV-1h68 virus strain has promising potential for effective treatment of canine mammary carcinoma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Gentschev, Ivaylo& Ehrig, Klaas& Donat, Ulrike& Hess, Michael& Rudolph, Stephan& Chen, Nanhai G.…[et al.]. 2010. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-494647

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Gentschev, Ivaylo…[et al.]. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-494647

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Gentschev, Ivaylo& Ehrig, Klaas& Donat, Ulrike& Hess, Michael& Rudolph, Stephan& Chen, Nanhai G.…[et al.]. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-494647

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-494647