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Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68
Joint Authors
Hess, Michael
Nolte, Ingo
Gentschev, Ivaylo
Donat, Ulrike
Ehrig, Klaas
Chen, Nanhai G.
Yu, Yong A.
Bullerdiek, Joern
Szalay, Aladar A.
Zhang, Qian
Stritzker, Jochen
Rudolph, Stephan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment.
Therefore, there is an urgent need to identify novel agents for therapy of this disease.
Recently, we reported that the oncolytic vaccinia virus GLV-1h68 could be a useful tool for therapy of canine mammary adenoma in vivo.
In this study we analyzed the therapeutic effect of GLV-1h68 against canine mammary carcinoma.
Cell culture data demonstrated that GLV-1h68 efficiently infected and destroyed cells of the mammary carcinoma cell line MTH52c.
Furthermore, after systemic administration, this attenuated vaccinia virus strain primarily replicated in canine tumor xenografts in nude mice.
Finally, infection with GLV-1h68 led to strong inflammatory and oncolytic effects resulting in significant growth inhibition of the tumors.
In summary, the data showed that the GLV-1h68 virus strain has promising potential for effective treatment of canine mammary carcinoma.
American Psychological Association (APA)
Gentschev, Ivaylo& Ehrig, Klaas& Donat, Ulrike& Hess, Michael& Rudolph, Stephan& Chen, Nanhai G.…[et al.]. 2010. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-494647
Modern Language Association (MLA)
Gentschev, Ivaylo…[et al.]. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-494647
American Medical Association (AMA)
Gentschev, Ivaylo& Ehrig, Klaas& Donat, Ulrike& Hess, Michael& Rudolph, Stephan& Chen, Nanhai G.…[et al.]. Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-494647
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494647