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Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection
المؤلفون المشاركون
Sutoh, Satoshi
Seki, Nobuyoshi
Aida, Yuta
Abe, Hiroshi
Ishiguro, Haruya
Itagaki, Munenori
Sugita, Tomonori
Miyazaki, Tamihiro
Aizawa, Yoshio
المصدر
Hepatitis Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Of 168 patients with chronic hepatitis B virus (HBV) infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV) (ADV group) and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group) for >1 year were enrolled.
For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores.
At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate (P=0.0424) and serum bone-specific alkaline phosphatase (BAP) (P=0.0228) concentrations were significantly higher in the ADV group than in the non-ADV group.
Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (P=0.0001), although there was no significant change in serum BAP concentration in the non-ADV group.
There was a significant positive correlation between the period of ADV therapy and ΔBAP (R2=0.2959, P=0.0160).
Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abe, Hiroshi& Seki, Nobuyoshi& Sugita, Tomonori& Aida, Yuta& Ishiguro, Haruya& Miyazaki, Tamihiro…[et al.]. 2013. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494836
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abe, Hiroshi…[et al.]. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-494836
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abe, Hiroshi& Seki, Nobuyoshi& Sugita, Tomonori& Aida, Yuta& Ishiguro, Haruya& Miyazaki, Tamihiro…[et al.]. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494836
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494836
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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