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Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection
Joint Authors
Sutoh, Satoshi
Seki, Nobuyoshi
Aida, Yuta
Abe, Hiroshi
Ishiguro, Haruya
Itagaki, Munenori
Sugita, Tomonori
Miyazaki, Tamihiro
Aizawa, Yoshio
Source
Hepatitis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Of 168 patients with chronic hepatitis B virus (HBV) infection-related liver disease, 20 patients who had received 100 mg of lamivudine plus 10 mg/day of adefovir dipivoxil (ADV) (ADV group) and 124 patients who had received 0.5 mg/day of entecavir or 100 mg/day of lamivudine (non-ADV group) for >1 year were enrolled.
For comparative analyses, 19 well-matched pairs were obtained from the groups by propensity scores.
At the time of enrollment, serum creatinine and phosphate concentrations were similar between the ADV and non-ADV groups; however, urinary phosphate (P=0.0424) and serum bone-specific alkaline phosphatase (BAP) (P=0.0228) concentrations were significantly higher in the ADV group than in the non-ADV group.
Serum BAP was significantly higher at the time of enrollment than before ADV administration in the ADV group (P=0.0001), although there was no significant change in serum BAP concentration in the non-ADV group.
There was a significant positive correlation between the period of ADV therapy and ΔBAP (R2=0.2959, P=0.0160).
Serum BAP concentration increased before increase in serum creatinine concentration and was useful for early detection of adverse events and for developing adequate measures for continuing ADV for chronic HBV infection-related liver disease.
American Psychological Association (APA)
Abe, Hiroshi& Seki, Nobuyoshi& Sugita, Tomonori& Aida, Yuta& Ishiguro, Haruya& Miyazaki, Tamihiro…[et al.]. 2013. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494836
Modern Language Association (MLA)
Abe, Hiroshi…[et al.]. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-494836
American Medical Association (AMA)
Abe, Hiroshi& Seki, Nobuyoshi& Sugita, Tomonori& Aida, Yuta& Ishiguro, Haruya& Miyazaki, Tamihiro…[et al.]. Elevation in Serum Concentration of Bone-Specific Alkaline Phosphatase without Elevation in Serum Creatinine Concentration Secondary to Adefovir Dipivoxil Therapy in Chronic Hepatitis B Virus Infection. Hepatitis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494836