Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats
المؤلفون المشاركون
Yehye, Wageeh A.
Kadir, Farkaad A.
Abdulla, Mahmood Ameen
Kassim, Normadiah M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The hepatoprotective activity of ethanolic extract from the leaves of Vitex negundo (VN) was conducted against thioacetamide- (TAA-) induced hepatic injury in Sprague Dawley rats.
The therapeutic effect of the extract was investigated on adult male rats.
Rats were divided into seven groups: control, TAA, Silymarin (SY), and VN high dose and low dose groups.
Rats were administered with VN extract at two different doses, 100 mg/kg and 300 mg/kg body weight.
After 12 weeks, the rats administered with VN showed a significantly lower liver to body weight ratio.
Their abnormal levels of biochemical parameters and liver malondialdehyde were restored closer to the normal levels and were comparable to the levels in animals treated with the standard drug, SY.
Gross necropsy and histopathological examination further confirmed the results.
Progression of liver fibrosis induced by TAA in rats was intervened by VN extract administration, and these effects were similar to those administered with SY.
This is the first report on hepatoprotective effect of VN against TAA-induced liver fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Yehye, Wageeh A.. 2013. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kadir, Farkaad A.…[et al.]. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-494894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Yehye, Wageeh A.. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر