![](/images/graphics-bg.png)
Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats
Joint Authors
Yehye, Wageeh A.
Kadir, Farkaad A.
Abdulla, Mahmood Ameen
Kassim, Normadiah M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The hepatoprotective activity of ethanolic extract from the leaves of Vitex negundo (VN) was conducted against thioacetamide- (TAA-) induced hepatic injury in Sprague Dawley rats.
The therapeutic effect of the extract was investigated on adult male rats.
Rats were divided into seven groups: control, TAA, Silymarin (SY), and VN high dose and low dose groups.
Rats were administered with VN extract at two different doses, 100 mg/kg and 300 mg/kg body weight.
After 12 weeks, the rats administered with VN showed a significantly lower liver to body weight ratio.
Their abnormal levels of biochemical parameters and liver malondialdehyde were restored closer to the normal levels and were comparable to the levels in animals treated with the standard drug, SY.
Gross necropsy and histopathological examination further confirmed the results.
Progression of liver fibrosis induced by TAA in rats was intervened by VN extract administration, and these effects were similar to those administered with SY.
This is the first report on hepatoprotective effect of VN against TAA-induced liver fibrosis.
American Psychological Association (APA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Yehye, Wageeh A.. 2013. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494894
Modern Language Association (MLA)
Kadir, Farkaad A.…[et al.]. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-494894
American Medical Association (AMA)
Kadir, Farkaad A.& Kassim, Normadiah M.& Abdulla, Mahmood Ameen& Yehye, Wageeh A.. Hepatoprotective Role of Ethanolic Extract of Vitex negundo in Thioacetamide-Induced Liver Fibrosis in Male Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-494894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494894