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Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice
المؤلفون المشاركون
Abraham, Nader G.
Puri, Nitin
Oury, Tim D.
Morita, Kiyoshi
Takahashi, Toru
Rezzani, Rita
Kawakami, Tomoko
Sodhi, Komal
Bellner, Lars
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Heme oxygenase (HO) system is one of the key regulators of cellular redox homeostasis which responds to oxidative stress (ROS) via HO-1 induction.
However, recent reports have suggested an inhibitory effect of ROS on HO activity.
In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals.
Experiments were performed in WT and EC-SOD(−/−) mice treated with and without HO inducer, cobalt protoporphyrin (CoPP).
EC-SOD(−/−) mice exhibited oxidative stress, renal histopathological abnormalities, elevated blood pressure, impaired endothelial function, reduced p-eNOS, p-AKT and increased HO-1 expression; although, HO activity was significantly (P<0.05) attenuated along with attenuation of serum adiponectin and vascular epoxide levels (P<0.05).
CoPP, in EC-SOD(−/−) mice, enhanced HO activity (P<0.05) and reversed aforementioned pathophysiological abnormalities along with restoration of vascular EET, p-eNOS, p-AKT and serum adiponectin levels in these animals.
Taken together our results implicate a causative role of insufficient activation of heme-HO-adiponectin system in pathophysiological abnormalities observed in animal models of chronic oxidative stress such as EC-SOD(−/−) mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kawakami, Tomoko& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Takahashi, Toru& Morita, Kiyoshi…[et al.]. 2012. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawakami, Tomoko…[et al.]. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-494906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kawakami, Tomoko& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Takahashi, Toru& Morita, Kiyoshi…[et al.]. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-494906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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