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Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice
Joint Authors
Abraham, Nader G.
Puri, Nitin
Oury, Tim D.
Morita, Kiyoshi
Takahashi, Toru
Rezzani, Rita
Kawakami, Tomoko
Sodhi, Komal
Bellner, Lars
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Heme oxygenase (HO) system is one of the key regulators of cellular redox homeostasis which responds to oxidative stress (ROS) via HO-1 induction.
However, recent reports have suggested an inhibitory effect of ROS on HO activity.
In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals.
Experiments were performed in WT and EC-SOD(−/−) mice treated with and without HO inducer, cobalt protoporphyrin (CoPP).
EC-SOD(−/−) mice exhibited oxidative stress, renal histopathological abnormalities, elevated blood pressure, impaired endothelial function, reduced p-eNOS, p-AKT and increased HO-1 expression; although, HO activity was significantly (P<0.05) attenuated along with attenuation of serum adiponectin and vascular epoxide levels (P<0.05).
CoPP, in EC-SOD(−/−) mice, enhanced HO activity (P<0.05) and reversed aforementioned pathophysiological abnormalities along with restoration of vascular EET, p-eNOS, p-AKT and serum adiponectin levels in these animals.
Taken together our results implicate a causative role of insufficient activation of heme-HO-adiponectin system in pathophysiological abnormalities observed in animal models of chronic oxidative stress such as EC-SOD(−/−) mice.
American Psychological Association (APA)
Kawakami, Tomoko& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Takahashi, Toru& Morita, Kiyoshi…[et al.]. 2012. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494906
Modern Language Association (MLA)
Kawakami, Tomoko…[et al.]. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-494906
American Medical Association (AMA)
Kawakami, Tomoko& Puri, Nitin& Sodhi, Komal& Bellner, Lars& Takahashi, Toru& Morita, Kiyoshi…[et al.]. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-494906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494906