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Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates
المؤلفون المشاركون
Blanco, Federico Carlos
Vazquez, Camila
Sasiain, María del Carmen
Bigi, Fabiana
López, Beatriz
Klepp, Laura
Rocha, Roxana Valeria
Schierloh, Pablo
Ritacco, Viviana
Balboa, Luciana
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-06
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response.
Recent studies have demonstrated that Mtb families found worldwide today differ in pathology, transmissibility, virulence, and development of immune response.
By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM) and from Haarlem (H) lineages were identified.
In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses.
We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins.
Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD, or anti-Mtb-surface IgG antibodies.
Therefore, the present results describe new Mtb antigens with potential application as biomarkers of TB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schierloh, Pablo& Klepp, Laura& Vazquez, Camila& Rocha, Roxana Valeria& Blanco, Federico Carlos& Balboa, Luciana…[et al.]. 2014. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-495022
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schierloh, Pablo…[et al.]. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-495022
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schierloh, Pablo& Klepp, Laura& Vazquez, Camila& Rocha, Roxana Valeria& Blanco, Federico Carlos& Balboa, Luciana…[et al.]. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-495022
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495022
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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