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Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates
Joint Authors
Blanco, Federico Carlos
Vazquez, Camila
Sasiain, María del Carmen
Bigi, Fabiana
López, Beatriz
Klepp, Laura
Rocha, Roxana Valeria
Schierloh, Pablo
Ritacco, Viviana
Balboa, Luciana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response.
Recent studies have demonstrated that Mtb families found worldwide today differ in pathology, transmissibility, virulence, and development of immune response.
By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM) and from Haarlem (H) lineages were identified.
In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses.
We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins.
Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD, or anti-Mtb-surface IgG antibodies.
Therefore, the present results describe new Mtb antigens with potential application as biomarkers of TB.
American Psychological Association (APA)
Schierloh, Pablo& Klepp, Laura& Vazquez, Camila& Rocha, Roxana Valeria& Blanco, Federico Carlos& Balboa, Luciana…[et al.]. 2014. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-495022
Modern Language Association (MLA)
Schierloh, Pablo…[et al.]. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-495022
American Medical Association (AMA)
Schierloh, Pablo& Klepp, Laura& Vazquez, Camila& Rocha, Roxana Valeria& Blanco, Federico Carlos& Balboa, Luciana…[et al.]. Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-495022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495022