JNK12 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression
المؤلفون المشاركون
Woo, Sang-Mi
Ko, Seong-Gyu
Shin, Yong Cheol
Cho, Sung-Gook
Choi, Youn Kyung
Choi, Hyeong Sim
Yun, Yee Jin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cancer cells acquire anticancer drug resistance during chemotherapy, which aggravates cancer disease.
MDR1 encoded from multidrug resistance gene 1 mainly causes multidrug resistance phenotypes of different cancer cells.
In this study, we demonstrate that JNK1/2 activation by an extract from the root of Morus alba L.
(White mulberry) reduces doxorubicin-resistant MCF-7/Dox cell viability by inhibiting YB-1 regulation of MDR1 gene expression.
When MCF-7 or MCF-7/Dox cells, where MDR1 is highly expressed were treated with an extract from roots or leaves of Morus alba L., respectively, the root extract from the mulberry (REM) but not the leaf extract (LEM) reduced cell viabilities of both MCF-7 and MCF-7/Dox cells, which was enhanced by cotreatment with doxorubicin.
REM but not LEM further inhibited YB-1 nuclear translocation and its regulation of MDR1 gene expression.
Moreover, REM promoted phosphorylation of c-Jun NH2-terminal kinase 1/2 (JNK1/2) and JNK1/2 inhibitor, SP600125 and rescued REM inhibition of both MDR1 expression and viabilities in MCF-7/Dox cells.
Consistently, overexpression of JNK1, c-Jun, or c-Fos inhibited YB-1-dependent MDR1 expression and reduced viabilities in MCF-7/Dox cells.
In conclusion, our data indicate that REM-activated JNK-cJun/c-Fos pathway decreases the viability of MCF-7/Dox cells by inhibiting YB-1-dependent MDR1 gene expression.
Thus, we suggest that REM may be useful for treating multidrug-resistant cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Youn Kyung& Cho, Sung-Gook& Choi, Hyeong Sim& Woo, Sang-Mi& Yun, Yee Jin& Shin, Yong Cheol…[et al.]. 2013. JNK12 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495103
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Youn Kyung…[et al.]. JNK12 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-495103
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Youn Kyung& Cho, Sung-Gook& Choi, Hyeong Sim& Woo, Sang-Mi& Yun, Yee Jin& Shin, Yong Cheol…[et al.]. JNK12 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-495103
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495103
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر