Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice

المؤلفون المشاركون

Huang, Liyong
Chen, Ying
Zhou, Wenke
Mo, Haizhen
Li, Juxiang
Zhang, Hao

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-03

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases.

In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and cytochrome c (cyt c) in cerebral cortex were detected.

This study showed that the alteration of mitochondrial membrane potential was an early event in SAH progression.

The trend of ATP production was similar to that of mitochondrial membrane potential, indicating that the lower the mitochondrial membrane potential, lesser the ATP produced.

Due to mitochondrial dysfunction, more cyt c was released in the SAH group.

Interestingly, the preadministration of tea polyphenols significantly rescued the mitochondrial membrane potential to basal level, as well as the ATP content and the cyt c level in the brain cortex 12 h after SAH.

After pretreatment with tea polyphenols, the neurological outcome was also improved.

The results provide strong evidence that tea polyphenols enhance neuroprotective effects by inhibiting polarization of mitochondrial membrane potential, increasing ATP content, and blocking cyt c release.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mo, Haizhen& Chen, Ying& Huang, Liyong& Zhang, Hao& Li, Juxiang& Zhou, Wenke. 2013. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495281

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Mo, Haizhen…[et al.]. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-495281

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mo, Haizhen& Chen, Ying& Huang, Liyong& Zhang, Hao& Li, Juxiang& Zhou, Wenke. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495281

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-495281