Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice
Joint Authors
Huang, Liyong
Chen, Ying
Zhou, Wenke
Mo, Haizhen
Li, Juxiang
Zhang, Hao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases.
In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and cytochrome c (cyt c) in cerebral cortex were detected.
This study showed that the alteration of mitochondrial membrane potential was an early event in SAH progression.
The trend of ATP production was similar to that of mitochondrial membrane potential, indicating that the lower the mitochondrial membrane potential, lesser the ATP produced.
Due to mitochondrial dysfunction, more cyt c was released in the SAH group.
Interestingly, the preadministration of tea polyphenols significantly rescued the mitochondrial membrane potential to basal level, as well as the ATP content and the cyt c level in the brain cortex 12 h after SAH.
After pretreatment with tea polyphenols, the neurological outcome was also improved.
The results provide strong evidence that tea polyphenols enhance neuroprotective effects by inhibiting polarization of mitochondrial membrane potential, increasing ATP content, and blocking cyt c release.
American Psychological Association (APA)
Mo, Haizhen& Chen, Ying& Huang, Liyong& Zhang, Hao& Li, Juxiang& Zhou, Wenke. 2013. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495281
Modern Language Association (MLA)
Mo, Haizhen…[et al.]. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-495281
American Medical Association (AMA)
Mo, Haizhen& Chen, Ying& Huang, Liyong& Zhang, Hao& Li, Juxiang& Zhou, Wenke. Neuroprotective Effect of Tea Polyphenols on Oxyhemoglobin Induced Subarachnoid Hemorrhage in Mice. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-495281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495281