High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression
المؤلفون المشاركون
Reinke, Petra
Unterwalder, Nadine
Meisel, Christian
Savvatis, Konstantinos
Schefold, Joerg C.
Volk, Hans-Dieter
Hammoud, Ben
Fotopoulou, Christina
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
High-mobility group box-1 (HMGB-1) protein is released during “late sepsis” by activated monocytes.
We investigated whether systemic HMGB-1 levels are associated with indices of monocytic activation/function in patients with sepsis-induced immunosuppression.
Methodology.
36 patients (31 male, 64±14 years) with severe sepsis/septic shock and monocytic deactivation (reduced mHLA-DR expression and TNF-α release) were assessed in a subanalysis of a placebo-controlled immunostimulatory trial using GM-CSF.
HMGB-1 levels were assessed over a 9-day treatment interval.
Data were compared to standardized biomarkers of monocytic immunity (mHLA-DR expression, TNF-α release).
Principle findings.
HMGB-1 levels were enhanced in sepsis but did not differ between treatment and placebo groups at baseline (14.6 ± 13.5 versus 12.5 ± 11.5 ng/ml, P=.62).
When compared to controls, HMGB-1 level increased transiently in treated patients at day 5 (27.8±21.7 versus 11.0±14.9, P=.01).
Between group differences were not noted at any other point of assessment.
HMGB-1 levels were not associated with markers of monocytic function or clinical disease severity.
Conclusions.
GM-CSF treatment for sepsis-induced immunosuppression induces a moderate but only transient increase in systemic HMGB-1 levels.
HMGB-1 levels should not be used for monitoring of monocytic function in immunostimulatory trials as they do not adequately portray contemporary changes in monocytic immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Unterwalder, Nadine& Meisel, Christian& Savvatis, Konstantinos& Hammoud, Ben& Fotopoulou, Christina& Volk, Hans-Dieter…[et al.]. 2010. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Unterwalder, Nadine…[et al.]. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-495344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Unterwalder, Nadine& Meisel, Christian& Savvatis, Konstantinos& Hammoud, Ben& Fotopoulou, Christina& Volk, Hans-Dieter…[et al.]. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر