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High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression
Joint Authors
Reinke, Petra
Unterwalder, Nadine
Meisel, Christian
Savvatis, Konstantinos
Schefold, Joerg C.
Volk, Hans-Dieter
Hammoud, Ben
Fotopoulou, Christina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
High-mobility group box-1 (HMGB-1) protein is released during “late sepsis” by activated monocytes.
We investigated whether systemic HMGB-1 levels are associated with indices of monocytic activation/function in patients with sepsis-induced immunosuppression.
Methodology.
36 patients (31 male, 64±14 years) with severe sepsis/septic shock and monocytic deactivation (reduced mHLA-DR expression and TNF-α release) were assessed in a subanalysis of a placebo-controlled immunostimulatory trial using GM-CSF.
HMGB-1 levels were assessed over a 9-day treatment interval.
Data were compared to standardized biomarkers of monocytic immunity (mHLA-DR expression, TNF-α release).
Principle findings.
HMGB-1 levels were enhanced in sepsis but did not differ between treatment and placebo groups at baseline (14.6 ± 13.5 versus 12.5 ± 11.5 ng/ml, P=.62).
When compared to controls, HMGB-1 level increased transiently in treated patients at day 5 (27.8±21.7 versus 11.0±14.9, P=.01).
Between group differences were not noted at any other point of assessment.
HMGB-1 levels were not associated with markers of monocytic function or clinical disease severity.
Conclusions.
GM-CSF treatment for sepsis-induced immunosuppression induces a moderate but only transient increase in systemic HMGB-1 levels.
HMGB-1 levels should not be used for monitoring of monocytic function in immunostimulatory trials as they do not adequately portray contemporary changes in monocytic immunity.
American Psychological Association (APA)
Unterwalder, Nadine& Meisel, Christian& Savvatis, Konstantinos& Hammoud, Ben& Fotopoulou, Christina& Volk, Hans-Dieter…[et al.]. 2010. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495344
Modern Language Association (MLA)
Unterwalder, Nadine…[et al.]. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-495344
American Medical Association (AMA)
Unterwalder, Nadine& Meisel, Christian& Savvatis, Konstantinos& Hammoud, Ben& Fotopoulou, Christina& Volk, Hans-Dieter…[et al.]. High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-495344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495344