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Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea
المؤلفون المشاركون
Li, Dichen
Jin, Zhongmin
Zhang, Weijie
Bian, Weiguo
He, Jiankang
Hao, Dingjun
Wang, Kunzheng
Lian, Qin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ.
However, the exact change of subchondral bone during osteochondral repair is still poorly understood.
In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model.
Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation.
Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks.
The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually.
Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage.
Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects.
Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Weijie& Lian, Qin& Li, Dichen& Wang, Kunzheng& Hao, Dingjun& Bian, Weiguo…[et al.]. 2014. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-495381
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Weijie…[et al.]. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-495381
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Weijie& Lian, Qin& Li, Dichen& Wang, Kunzheng& Hao, Dingjun& Bian, Weiguo…[et al.]. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-495381
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-495381
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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